What are the potential negative side effects of NSAIDs? Approximately 10-50% of patients suffer with gastrointestinal issues such as abdominal pain, diarrhea, bloating, heartburn, and upset stomach. Furthermore, 15% develop ulcers after long-term use. What is a Cox-1 enzyme? Cyclooxygenase-1 (Cox-1) is an enzyme that is present at sites of inflammation as well as in the stomach. The Cox-1 enzyme of the stomach produces prostaglandins, chemical messenger. These prostaglandins protect the lining of the stomach from the acids that it contains. When Cox-1 enzymes are inhibited, inflammation is reduced; however, the integrity of the stomach lining is compromised. This reduction to the stomach leads to ulcers and other gastrointestinal issues. What is a Cox-2 enzyme? Cyclooxygenase-2 (Cox-2) produces prostaglandins also but solely at the sites of inflammation. Therefore, hindering these enzymes reduces inflammation. What is a Cox-2 Inhibitor? Cox-2 inhibitors are a new class of nonsteroidal anti-inflammatory drugs (NSAIDs). Because they selectively block the Cox-2 enzyme and not the Cox-1 enzyme, these drugs are uniquely different from traditional NSAIDs. Why were Cox-2 Inhibitors created? Cox-2 Inhibitors were created to reduce inflammation without compromising the stomach lining. Therefore, inflammation sufferers will achieve relief without being at risk for ulcers. What is the danger surrounding Cox-2 Inhibitors? (i.e., Celebrex, Vioxx, and Bextra) Although in theory Cox-2 Inhibitors are a great solution, they have some definite health considerations you need to know before you take them. Cox-2 inhibitors have been manufactured in one set dosage. The only available dosage is at such a high level there is an extremely high risk for strokes and heart attacks. Without the option for healthcare professionals to individualize prescriptions for their patients, all patients are receiving the same amount regardless of height, weight, sex, medical history etc. The negative risk have been so great, the FDA formed an Advisory Committee consisting of 32 experts who agree that these Cox-2 Inhibitors cause too high a risk for strokes and heart attacks. They recommend that healthcare providers to be very cautious as to which patients they prescribe Cox-2 despite the pharmaceutical companies flashy advertising. Are there natural alternatives to Cox-2 Inhibitors? There are many viable natural options available for individuals suffering from inflammatory diseases such as arthritis and overuse type conditions such as tendonitis and bursitis. Specifically, there is an ingredient called Nexrutine offered by Next Pharmaceuticals that works on the Cox 2 enzyme without platelet aggregation or risk of cardiovascular health. Nexrutine taken by itself is a very good natural pain reliever. Optimal Therapeutics produces a Nexrutine ingredient based product called Phosoplex. The product promotes healthy joint function and also helps to alleviate pain and swelling. This cumulative effect allows for the repair of damaged joints. What makes the product so effective? In addition to Nexrutine, Phosoplex contains a synergistic blend of powerful ingredients such as Hyaluronic Acid, MSM, Glucosamine, BioCell Collagen II. Overall Phosoplex is as effective as any other natural joint pain reliever on the market today. Based on current research and recent problems with pharmaceutical pain relieving drugs, natural alternative ingredients like Nexrutine and natural formulas like Phosoplex are the future for safe and effective pain management. |
